Cannon JE, Upton PD, Smith JC, Morrell NW. Intersegmental vessel formation in zebrafish: requirement for VEGF but not BMP signalling revealed by selective and non-selective BMP antagonists. Br J Pharmacol. 2010;161(1):140-9.

Pardali E, Goumans, MJ, ten Dijke P. Signaling by members of the TGFbeta family in vascular morphogenesis and disease. Trends in Cell Biology, 2010;20:556-67.


Bernardo AS, Faial T, Gardner L, Niakan KK, Ortmann D, Senner CE, Callery EM, Trotter MW, Hemberger M, Smith JC, Bardwell L, Moffett A, Pedersen RA. BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell. 2011;9(2):144-55.

Steinbicker AU, Liu H, Jiramongkolchai K, Malhotra R, Choe EY, Busch CJ, Graveline AR, Kao SM, Nagasaka Y, Ichinose F, Buys ES, Brouckaert P, Zapol WM, Bloch KD. Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Nitric Oxide. 2011;25(3):294-302.

Weng M, Baron DM, Bloch KD, Luster AD, Lee JJ, Medoff BD. Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2011;301(6):L927-36.

Malhotra R, Hess D, Lewis GD, Bloch KD, Waxman AB, Semigran MJ. Vasoreactivity to inhaled nitric oxide with oxygen predicts long-term survival in pulmonary arterial hypertension. Pulm Circ. 2011;1(2):250-258.

Yang X, Long L, Reynolds PN, Morrell NW. Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells. Pulm Circ. 2011;1(1):103-10.

Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KD. Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood. 2011;118(15):4224-30. Epub 2011 Aug 12.

Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011;117(18):4915-23. Epub 2011 Mar 10.

Egorova AD, Padmini Khedoe PPSJ, Goumans MJ, Yoder BK, Surya M, SM, ten Dijke P, Poelmann RE, and Hierck BP (2011) Lack of primary cilia primes shear-induced Endothelial-to-Mesenchymal Transition. Circ Res 2011;108:1093-1101.

van Meeteren L, Goumans MJ, ten Dijke P. TGF-b receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy. Curr Pharm Biotechnol 2011;12(12):2108-20.

Orlova V, Liu Z, Goumans MJ, ten Dijke P. Controlling angiogenesis by two unique TGF-b type I receptors signaling pathways. Histol and Histopathol 2011;26:1219-1230.

Chan, M-C, Weisman, A.S., Kang, H., Nguyen, P.H., Hickman, T., Mecker, S.V., Hill, N.S., Lagna, G., and Hata, A. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the BMP signaling pathway, Mol Cell Bio. 2011;31(3):517-30.

Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. Down-reglation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and Bone morphogenetic protein 4. J Biol Chem 2011;286(32): 28097-28110.

Wu, C., So, J., Davis-Dusenbery, BN, Qi, HH, Bloch, DB, Shi, Y. Lagna, G, and Hata, A. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute 2. Mol Cell Biol. 2011;31(23):4760-74.

Bernardo AS, Faial T, Gardner L, Niakan KK, Ortmann D, Senner CE, Callery EM, Trotter MW, Hemberger M, Smith JC, Bardwell L, Moffett A, Pedersen RA. BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell. 2011;9(2):144-55.


Callery EM, Park CY, Xu X, Zhu H, Smith JC, Thomsen GH. Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins. Open Biol. 2012;2(4):120060

Evans AL, Faial T, Gilchrist MJ, Down T, Vallier L, Pedersen RA, Wardle FC, Smith JC. Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells. PLoS One. 2012;7(3):e33346.

Baron DM, Yu B, Lei C, Bagchi A, Beloiartsev A, Stowell CP, Steinbicker AU, Malhotra R, Bloch KD, Zapol WM. Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide. Anesthesiology. 2012;116(3):637-47.

Buys ES, Raher MJ, Kirby A, Shahid M, Baron DM, Hayton SR, Tainsh LT, Sips PY, Rauwerdink KM, Yan Q, Tainsh RE, Shakartzi HR, Stevens C, Decaluwé K, Rodrigues-Machado Mda G, Malhotra R, Van de Voorde J, Wang T, Brouckaert P, Daly MJ, Bloch KD. Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice. J Clin Invest. 2012;122(6):2316-25. Erratum in: J Clin Invest. 2012;122(8):3024. Epub 2012 May 8. Erratum in: J Clin Invest. 2012;122(8):3024.

Zhao J, Bolton EM, Ormiston ML, Bradley JA, Morrell NW, Lever AM. Late outgrowth endothelial progenitor cells engineered for improved survival and maintenance of function in transplant-related injury. Transpl Int. 2012;(2):229-41.

Davies RJ, Holmes AM, Deighton J, Long L, Yang X, Barker L, Walker C, Budd DC, Upton PD, Morrell NW. BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of pro-inflammatory cytokines. Am J Physiol Lung Cell Mol Physiol. 2012;302(6):L604-15.

Cahill E, Costello CM, Rowan SC, Harkin S, Howell K, Leonard MO, Southwood M, Cummins EP, Fitzpatrick SF, Taylor CT, Morrell NW, Martin F, McLoughlin P. Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation. 2012;125(7):920-30.

Park JE, Shao D, Upton PD, Desouza P, Adcock IM, Davies RJ, Morrell NW, Griffiths MJ, Wort SJ. BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production. PLoS One. 2012;7(1):e30075.

Caruso P, Dempsie Y, Stevens HC, McDonald RA, Long L, Lu R, White K, Mair KM, McClure JD, Southwood M, Upton P, Xin M, van Rooij E, Olson EN, Morrell NW, MacLean MR, Baker AH. A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circ Res. 2012;111(3):290-300.

Ormiston ML, Chang C, Long LL, Soon E, Jones D, Machado R, Treacy C, Toshner MR, Campbell K, Riding A, Southwood M, Pepke-Zaba J, Exley A, Trembath RC, Colucci F, Wills M, Trowsdale J, Morrell NW. Impaired natural killer cell phenotype and function in idiopathic and heritable pulmonary arterial hypertension. Circulation. 2012;126(9):1099-109.

White RJ, Morrell NW. Understanding the low penetrance of bone morphogenetic protein receptor 2 gene mutations: another needle in the haystack. Circulation. 2012;126(15):1818-20.

Cai J, Pardali E, Sanchez-Duffhues G, ten Dijke P. BMP signaling in vascular diseases, Febs Letters, 2012;586:1993-2002.

Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32(3):613-22. Epub 2012 Jan 5.

Kang, H.,  Davis-Dusenbery, D., Nguyen, P.H., Lal, A., Lieberman, J., Van Aelst, L. Lagna, G, and Hata, A. BMP4 modulates vascular smooth muscle cell phenotype through downregulation of the desicator of cytokinesis (DOCK) family proteins by miR-21. J. Biol. Chem, 2012;287, 3976-86.

Wang, D., Prakash, J. Nguyen, P., Davis-Dusenbery, B.D., Hill, N.S., Layne, M.D., Hata, A., and Lagna, G. Bone Morphogenetic Protein signaling in vascular disease: anti-inflammatory action through Myocardin-related transcription factor A. J. Biol. Chem, 2012;287(33):28067-77.

Wu X, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia Y. Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent.  PLoS One. 2012;7(9):e44622. doi: 10.1371/journal.pone.0044622. Epub 2012 Sep 13.

Liu Z, Afink G, ten Dijke P. (2012) Soluble fms-like tyrosine kinase 1 and soluble Endoglin are elevated circulating anti-angiogenic factors in pre-eclampsia. Pregnancy Hypertention, in press.

Wu X, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia Y. “Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.” PLoS ONE, in press, 2012.

Komatsu Y, Yu PB, Kamiya N, Pan H, Fukuda T, Scott GJ, Ray MK, Yamamura KI, Mishina Y., “Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice.”  J Bone Miner Res. 2012 Dec 21.

Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB and DiRenzo J.  “DNp63a Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells.” Cancer Research, 2012, in press.


Malhotra R, Paskin-Flerlage S, Zamanian RT, Zimmerman P, Schmidt JW, Deng DY, Southwood M, Spencer R, Lai CS, Parker W, Channick RN, Morrell NW, Elliott CG, Yu PB. “Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension.”  Pulmonary Circulation, 2013, in press.

Review Articles
Morrell NW. “Genetics of pulmonary arterial hypertension: do the molecular findings have translational value?” F1000 Biol Rep. 2010 Mar 25;2. pii: 22.

Li W, Dunmore BJ, Morrell NW. Bone morphogenetic protein type II receptor mutations causing protein misfolding in heritable pulmonary arterial hypertension. Proc Am Thorac Soc. 2010;(6):395-8.

Davis-Dusenbery, BN and Hata, A. Smad-mediated miRNA processing- a critical role for a conserved RNA sequence., RNA Biology, 2011;8(1):71-76.

Hata, A. and Davis-Dusenbery, BD. Regulation of pri-miRNA Processing Through Smads. Adv. Exp. Med. Biol. 2011;700:15-27.

Kang, H. and Hata, A. MicroRNA regulation of smooth muscle gene expression and phenotype. Curr Opin. in Hematology, 2012;19(3):224-31.

Blahna, MT and Hata, A. Smad-mediated regulation of microRNA biosynthesis. FEBS Letters. 2012;586(14):1906-12.

McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH. MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovasc Res. 2012;93(4):594-604.

Books and Chapters

Hata, A. and Davis, BD. Regulation of vascular smooth muscle cell phenotype by the TGFbeta superfamily of growth factor signaling. Advances in Pulmonary Disease Editor: Yong-Xiao Wong, Research Signpost, 2011.